Efficacy of Bitter Blockers on Taste Perception in Children and Adults (BL)

Monell Chemical Senses Center

Status: Completed

Conditions: Healthy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01407939

1R01DC011287-01 (U.S. NIH Grant/Contract)

809789

Details and patient eligibility

About

This proposal describes 2 basic research studies that will be conducted sequentially. Study 1 will test the efficacy of both classic and newly developed "generally recognized as a safe" (GRAS) bitter blockers on the perceived bitterness and acceptance of different classes of bitter-tasting compounds by children and compare their responses to adults. Because variations among and between children and adults in terms of sensitivity to different bitter compounds are due in part to genetically determined receptor variation, the investigators will consider genotype when assessing how well bitter blockers perform. In Study 2, the investigators aim to evaluate different methods (forced-choice procedures, hedonic face scales) used for testing children to determine their reliability and reproducibility.

Enrollment: 215 patients

Sex: All

Ages: 3+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, term children of either sex and all races/ethnicities will be eligible for this study.
• Children must be between 3 and 10 years of age.

Exclusion criteria

• Children who are on any medications that may alter taste sensitivity
• Mothers who are pregnant

Trial design

215 participants in 1 patient group

Children, Adults

Description:

3- to 15-year old children and their parent (adults