Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy

National Taiwan University

Status and phase

Enrolling

Phase 4

Conditions

Radiation Therapy Recipient

BOTOX

Head and Neck Cancer

Trismus

Treatments

Drug: Echo-guided Botox injection

Procedure: echo-guided normal saline injection

Study type

Interventional

Funder types

Other

Identifiers

NCT06734598

202410133MINA

Details and patient eligibility

About

Trismus is a common side effect in head and neck cancer patients after radiation therapy. This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients.

In this project, Botulinum toxin will be injected into the masticatory muscles (medial pterygoid and masticatory muscles), combined with oral rehabilitation exercises, to reduce the patient's masticatory muscle tension and spasm. Patient's mouth opening range, quality of life, trismus condition and pain will be evaluated to understand its efficacy.

Enrollment

120 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged over 18 years old;
Head and neck cancer patients must have completed radiotherapy for at least 3 months;
Those whose mouth-opening distance is less than or equal to 3.5 cm (the functional cut-off point of trismus) and who have tightness or pain in the masticatory muscles;
Medical condition is stable;

Exclusion criteria

Those who have undergone surgery on their masticatory muscles;
Patients with obvious muscle atrophy or complete fibrosis of masticatory muscles ;
Those with tumor recurrence at the time of admission;
Those whose vital signs are unstable due to acute illness.