Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block

Cairo University (CU)

Status and phase

Completed

Phase 3

Conditions

Post Operative Pain

Treatments

Procedure: genicular nerve block using bupivacaine and magnesium

Procedure: genicular nerve block using bupivacaine and normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT06520475

N-157-2024

Details and patient eligibility

About

It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves .

No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block

Enrollment

94 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

American Society of Anesthesiologist (ASA) I or II physical status.
Between 18 and 70 years of age.
Both genders.
Patients undergoing total knee replacement surgery.

Exclusion criteria

Patient refusal.
ASA Ⅲ and Ⅳ patients.
Known allergy to the study drugs.
Hypermagnesemia.
Central or peripheral neurological disease.
Pregnancy.
Drug or alcohol abuse.
Localized infection at the site of the block.
Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)