Efficacy of Buprenorphine for Treatment of Acute Pain

Tehran University of Medical Sciences

Status and phase: Completed; Phase 4

Conditions: Acute Pain

Treatments: Drug: Morphine; Drug: Buprenorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01298297

TUMS-THESIS 88

Details and patient eligibility

About

The purpose of this study is to determine whether sublingual buprenorphine is effective in the treatment of acute pain in adult patients with extremity bone fractures

Enrollment: 80 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of extremity bone fracture Age>16 years Acute pain of score 3 or greater on numerical rating scale

Exclusion criteria

Long term use of opium or opioids/dependence Previous administration of analgesic Known sensitivity to opioids Pregnant women History of medical problems (liver, kidney, heart, hematologic)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

Buprenorphine + Placebo

Active Comparator group

Treatment:

Drug: Buprenorphine

Morphine + Placebo

Placebo Comparator group

Treatment:

Drug: Morphine