Efficacy of Buprenorphine on Postoperative Endodontic Analgesia (EBPEA)

University Hospitals (UH)

Status and phase: Terminated; Phase 1

Conditions: Postoperative Pain

Treatments: Drug: Sterile saline; Drug: lidocaine, epinephrine (Local anesthetic); Drug: Buprenorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT03268278

UHClevelandMCBupStudy

Details and patient eligibility

About

To see whether the addition of buprenorphone to local anesthesia will lengthen postoperative analgesia for endodontic pain

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• persons with preoperative pain to percussion of a tooth with pulpal disease requiring endodontic therapy, healthy individuals, ASA Class I and II, no known allergies to the drugs being administered

Exclusion criteria

• pregnancy, allergy to buprenorphine, allergy to local anesthetic

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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10 participants in 2 patient groups, including a placebo group

buprenorphine and local anesthetic

Active Comparator group

Description:

buprenorphine added to local anesthetic

Treatment:

Drug: Buprenorphine

Drug: lidocaine, epinephrine (Local anesthetic)

sterile saline and local anesthetic

Placebo Comparator group

Description:

sterile saline (placebo) added to local anesthetic

Treatment:

Drug: lidocaine, epinephrine (Local anesthetic)

Drug: Sterile saline