Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults

Mass General Brigham

Status

Completed

Conditions

Attention Deficit Hyperactivity Disorder (ADHD)

Substance Use Disorder (SUD)

Treatments

Drug: Bupropion SR

Study type

Interventional

Funder types

Other

Identifiers

NCT01270555

1999-P-009198

Details and patient eligibility

About

The investigators propose to conduct an open study to evaluate the efficacy and tolerability of Bupropion SR using clinically relevant doses in ADHD adults with a recent history of or current substance use disorders. We hypothesize that Bupropion SR will be effective in treating ADHD in this population.

Enrollment

32 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female outpatients 18 years old or older, up to 60 years old.
Patients with the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview.
Patients within the past 6 months known to abuse or to be dependent on alcohol or any drug (nicotine addiction not included)

Exclusion criteria

Any clinically unstable medical condition
Clinically significant abnormal baseline laboratory values
Mental retardation (I.Q. <75) or Organic brain disorders
Seizure disorder
Patients with a history or an eating disorder including anorexia or bulimia nervosa
Pregnant or nursing females
Patients with current bipolar disorder
Psychotic disorder of any type
Patients on psychotropics known to treat ADHD (i.e. stimulants, tricyclics)
Patients receiving psychotherapy known to treat ADHD (i.e. cognitive or cognitive/behavioral psychotherapy)
Patients demonstrating active withdrawal from substance abuse