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A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis
Full description
This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib to placebo measuring the time to onset of acute pain in a paced 20-minute walk.
40 subjects will be enrolled
Enrollment
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Inclusion criteria
Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline
Exclusion criteria
Non-pregant, non-lactating Able to stop active arthritis medication for washout Cardiovascular risk factors Abnormal EKG -
Primary purpose
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Interventional model
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Data sourced from clinicaltrials.gov
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