Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

University Hospitals (UH)

Status and phase: Completed; Phase 4

Conditions: Knee Osteoarthritis

Treatments: Drug: celecoxib

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00194090

06-04-41

Details and patient eligibility

About

A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis

Full description

This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib to placebo measuring the time to onset of acute pain in a paced 20-minute walk.

40 subjects will be enrolled

Enrollment: 40 patients

Sex: All

Ages: 45 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline

Exclusion criteria

Non-pregant, non-lactating Able to stop active arthritis medication for washout Cardiovascular risk factors Abnormal EKG -

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind