Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy

Diaa Eldin Taha Ramadan Mohamed

Status: Unknown

Conditions: Nephrolithiasis

Treatments: Drug: Ciprofloxacin; Drug: Levofloxacin

Study type: Interventional

Funder types: Other

Identifiers

NCT04374188

RS/19.23

Details and patient eligibility

About

Efficacy of ciprofloxacin therapy in avoidance of sepsis in patient undergoing percutanous nephrolithotomy. A randomized controlled trial.

Full description

To figure out the value of oral ciprofloxacin medication in ameliorate the outcome of renal nephrolithiasis extraction via the endoscope as regard the sepsis.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patient 18 years or older
• Stones ≥ 2 cm and/or mild to moderate hydronephrosis
• Sterile mid urine stream

Exclusion criteria

• Patients with a stent, nephrostomy tube or indwelling catheter
• Renal failure
• Fever before surgery
• Previous manipulation/procedure
• Concomitant bladder stone or tumour
• Patients with active UTI
• Contralateral renal/ureteric stone

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

ciprofloxacin

Active Comparator group

Description:

ciprofloxacin tablets

Treatment:

Drug: Ciprofloxacin

levofloxacin

Active Comparator group

Description:

levofloxacin tablets

Treatment:

Drug: Levofloxacin