Efficacy of Cognitive Training in Subjective Memory Impairment

Asan Medical Center

Status: Completed

Conditions: Memory Loss

Treatments: Behavioral: lifestyle modification; Behavioral: cognitive training

Study type: Interventional

Funder types: Other

Identifiers

NCT02555774

YJeongHong

Details and patient eligibility

About

This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.

Full description

Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.

Enrollment: 65 patients

Sex: All

Ages: 55 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB)
• Clinical dementia rating (CDR) score of 0
• Subjects with at least 3 years of formal education

Exclusion criteria

• Subjects with mild cognitive impairment or dementia
• Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor
• Subjects with uncontrolled severe medical conditions according to investigator's opinion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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65 participants in 3 patient groups

cognitive training

Experimental group

Description:

Cognitive training programs 2 times a week for 3 months (totally 24 sessions) for 90 minutes per session. Lifestyle modification is educated first, then weekly phone call for lifestyle modification is done by investigators.

Treatment:

Behavioral: lifestyle modification

Behavioral: cognitive training

lifestyle modification

Active Comparator group

Description:

This group receives only lifestyle modification for 3 months. Lifestyle modification is educated at the first, then weekly phone call for lifestyle modification is done by investigators. The method of lifestyle modification is same with the first arm.

Treatment:

Behavioral: lifestyle modification

No intervention

No Intervention group

Description:

This group receives no intervention.