Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
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About
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative and positive mothers in clearing placental parasitemia at delivery. If intermittent protective SP/AS treatment is equally efficacious and safe as intermittent protective SP, such a regimen could be adapted for programmatic use as a potentially more durable alternative to SP monotherapy in areas of increasing SP resistance.
Enrollment
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Inclusion criteria
- Women 15 years of age or older
- First or second pregnancy between 16 and 36 weeks gestation
Exclusion criteria
- Pregnancy prior to 16 weeks or after 36 weeks gestation
- Third or later pregnancy;
- Report previous allergic reactions to SP, AS, or unknown antimalarials;
- If the distance to their home is too great or too inaccessible for follow-up;
- Child's father refuses the woman's participation
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Interventional model
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Data sourced from clinicaltrials.gov
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