Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth

Nourhan M.Aly

Status and phase: Completed; Phase 2

Conditions: Pulp Necroses

Treatments: Biological: Blood clot scaffold combined with PRF; Biological: Blood clot scaffold

Study type: Interventional

Funder types: Other

Identifiers

NCT04390854

blood clot/ PRF & regeneration

Details and patient eligibility

About

The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.

Full description

30 immature necrotic permanent teeth in patients will be allocated and divided into two groups. Group 1 will be treated by regenerative procedure using blood clot as a scaffold and Group 2 will be treated with regenerative procedures using combined blood clot and Platelet rich fibrin as a scaffold.

Enrollment: 30 patients

Sex: All

Ages: 8 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Necrotic incisors with immature roots
• Pulp space not needed for post and core.
• The patient has to be free from any coagulation disorders, with normal platelets count.
• Good oral hygiene
• Cooperative patient

Exclusion criteria

• Internal or external root resorption.
• Root fracture and/or alveolar fracture.
• Previous root canal treatment.
• Medically compromised patients
• Uncooperative patient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Induced blood clot scaffold

Active Comparator group

Treatment:

Biological: Blood clot scaffold

Induced blood clot scaffold combined with Platelet rich fibrin

Experimental group

Treatment:

Biological: Blood clot scaffold combined with PRF