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Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Intercostal Nerve Block for Chronic Post-thoracotomy Pain

A

Affiliated Hospital of Nantong University

Status

Enrolling

Conditions

Nerve Block

Treatments

Other: intercostal nerve block
Drug: ropivacaine + compound betamethasone
Other: lateral intercostal nerve block

Study type

Interventional

Funder types

Other

Identifiers

NCT05556122
2022-K107-01

Details and patient eligibility

About

The patients were divided into two groups by random number method: GroupRD1 group and GroupRD2 group were given general anesthesia and intercostal nerve block.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml.

Full description

The RD1 group received ultrasound-guided intercostal nerve block at the incision before anesthesia induction, and the RD2 group received ultrasound-guided intercostal nerve block at the lateral costal Angle before anesthesia induction.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. 18-70 years old
  2. ASA grade I-III
  3. BMI: 18.5-28kg/m2
  4. Type of surgery: elective thoracoscopic lung mass resection
  5. Informed consent has been signed by the patient and/or family members

Exclusion criteria

  1. game anesthesia or sugar cortical hormone drugs allergic
  2. preoperative use of opioid medicines
  3. serious blood coagulation dysfunction
  4. serious heart, lung, liver and renal insufficiency
  5. put, chemotherapy, and glucocorticoid immunosuppressive therapy history or diseases of the immune system
  6. peptic ulcer
  7. newly gastrointestinal surgery
  8. has a history of thoracic surgery
  9. is the central nervous system disease
  10. Other glucocorticoids should be used with caution in patients such as fractures, wound repair, corneal ulcers, hyperadrenocortical disease, diabetes mellitus, pregnant women, etc.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

100 participants in 2 patient groups

intercostal nerve block at the incision
Experimental group
Description:
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
Treatment:
Other: intercostal nerve block
Drug: ropivacaine + compound betamethasone
lateral intercostal nerve block at costal angle
Active Comparator group
Description:
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
Treatment:
Other: lateral intercostal nerve block
Drug: ropivacaine + compound betamethasone

Trial contacts and locations

1

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Central trial contact

YiBin Qin

Data sourced from clinicaltrials.gov

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