Efficacy of Corneal Cross-Linking (CXL) in the Treatment of Pediatric Keratoconus

Al-Azhar University

Status: Completed

Conditions: Keratoconus

Treatments: Procedure: Crosslinking

Study type: Interventional

Funder types: Other

Identifiers

NCT07080983

Pediatric Keratoconus

Details and patient eligibility

About

This prospective interventional study investigates the efficacy of corneal cross-linking (CXL) in managing progressive keratoconus in pediatric patients. The procedure involved standard epithelium-off CXL, and patients were followed to assess outcomes such as visual acuity, keratometric stability, and corneal thickness.

Enrollment: 20 patients

Sex: All

Ages: 10 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 8 and 18 years
• Clinical and topographic diagnosis of keratoconus based on the Belin/Ambrosio Enhanced Ectasia Display
• Evidence of progression within the past 6-12 months (e.g., an increase in maximum keratometry (Kmax) by ≥1.0 diopter, a decrease in minimal corneal thickness by ≥10 µm, or deterioration in visual acuity not attributable to other causes

Exclusion criteria

• Corneal scarring or opacities.
• Active ocular infection or inflammation.
• Prior ocular surgery or trauma.
• Autoimmune or connective tissue disorders.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Cross-linking

Other group

Treatment:

Procedure: Crosslinking