Efficacy of Dexamethasone Added to Ramosetron for Preventing Postoperative Nausea and Vomiting in Highly Susceptible Patients Following Spine Surgery

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Vomiting; Nausea

Treatments: Drug: ramosetron with saline; Drug: ramosetron with dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT01013012

4-2007-0388

Details and patient eligibility

About

The purpose of this study is to study the efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery.

Enrollment: 94 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females
• Ages 18 to 65 years old

Exclusion criteria

• Patients who is taking steroid or who had been treated for the gastrointestinal disease
• Patients who have troubles with the kidney or liver
• Patients transferring to the ICU after the surgery
• overfat patients
• Patients who had taken antiemetics within 24 hours before the surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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94 participants in 2 patient groups

Group A

Active Comparator group

Description:

Group A : saline 1 ml + ramosetron 6μg/kg

Treatment:

Drug: ramosetron with saline

Group B

Experimental group

Description:

Group B : dexamethasone 4 mg + ramosetron 6μg/kg

Treatment:

Drug: ramosetron with dexamethasone