Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation

Sohag University

Status: Enrolling

Conditions: Propofol

Treatments: Drug: Dexmedetomidine-Propofol; Drug: Ketamine-Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT06756594

Soh-Med-24-11-02MS

Details and patient eligibility

About

This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I to II.
• Age between 18 and 60 years.
• Both sexes.

Exclusion criteria

• Having severe heart, lung, liver disease, kidney failure, or bleeding disorder.
• Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Dexmedetomidine-Propofol for sedation during gastrointestinal endoscopy

Active Comparator group

Description:

efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Treatment:

Drug: Dexmedetomidine-Propofol

Ketamine-Propofol for sedation during gastrointestinal endoscopy

Active Comparator group

Description:

efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Treatment:

Drug: Ketamine-Propofol