Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain

National Cancer Institute, Egypt

Status: Enrolling

Conditions: Analgesia

Treatments: Drug: Bupivacaine + Magnesium; Drug: Bupivacaine + Dexmedetomidine; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT05851768

N-80-2022/NSC

Details and patient eligibility

About

Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 65 years.
• Male and female sexes.
• ASA I-II.,III
• Cancer patients undergoing thoracotomy incisions
• Body mass index (BMI) from 18.5 to 30 kg/m2

Exclusion criteria

• Patient refusal
• Known allergy to any of the used drugs
• Low platelet count, any coagulation defect

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Erector spinae plane block with 0.25% bupivacaine

Active Comparator group

Description:

Patients will receive ultrasound guided ESPB with 0.25% bupivacaine

Treatment:

Drug: Bupivacaine

Erector spinae plane block with 0.25% bupivacaine and Magnesium

Experimental group

Description:

Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and magnesium

Treatment:

Drug: Bupivacaine + Magnesium

Erector spinae plane block with 0.25% bupivacaine and Dexmedetomidine

Experimental group

Description:

Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and dexmedetomidine

Treatment:

Drug: Bupivacaine + Dexmedetomidine