Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients

Chulalongkorn University

Status: Completed

Conditions: Osteoarthritis; Diacerein; Ocular Surface Disease

Treatments: Drug: Diacerein

Study type: Observational

Funder types: Other

Identifiers

NCT04351100

IRB No. 469/62

Details and patient eligibility

About

Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Osteoarthritis with
2. Ocular surface index score ≥ 13 with
3. Corneal staining score ≥ 3

Exclusion criteria

1. Allergic to diacerein
2. Use Cyclosporin within 30 days
3. Eyelid problem
4. Change artificial tear while in the study
5. Pregnancy or breast feeding

Trial design

34 participants in 1 patient group

Diacerein group

Description:

Osteoarthritis and dry eye patients treated with Diacerein

Treatment:

Drug: Diacerein