Efficacy of Dialectical Behavior Therapy Versus CAMS-informed Supportive Psychotherapy on Self Harming Behavior (DiaS)

Mental Health Services in the Capital Region, Denmark

Status: Completed

Conditions: Borderline Personality Disorder; Suicide

Treatments: Behavioral: DBT; Behavioral: CAMS

Study type: Interventional

Funder types: Other

Identifiers

NCT01512602

RHP-DiaS-002

Details and patient eligibility

About

Purpose: The purpose of this study is to investigate the efficacy of Dialectical Behavior Therapy (DBT) versus CAMS (Collaborative Assessment and Management of Suicidality) -informed supportive psychotherapy on the risk of self-harm acts and suicide attempts in patients with self behavior and personality traits within the spectrum of borderline personality disorder.

Hypothesis: The hypothesis is 16 weeks of treatment with Dialectical Behavior Therapy (DBT) after a defined manual has a higher efficacy than CAMS-informed supportive psychotherapy on self-harm acts, suicide attempts, suicidal ideation, depressive symptoms, impulsiveness and consumption of hospital services in patients with symptoms within the spectrum of borderline personality disorder (BDP).

Method: The investigators will include 160 patients in the randomized trial to investigate whether 16 weeks of DBT-treatment as a higher efficacy than CAMS-informed supportive psychotherapy on the risk of self-harm acts and suicide attempts in patients with self-harm behavior and personality traits within the spectrum of borderline personality disorder. The trial will meet strict criteria for high quality randomized trials, and will hopefully help to establish evidence for the treatment of this patient group at higher risk of later suicide. There will be performed follow up interviews after 16 weeks, 28 weeks and 52 weeks.

Enrollment: 108 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 years of age.
• Newly suicide attempt within one month of the inclusion date.
• A minimum of two characteristics in the DSM-IV Borderline Personality Disorder (BPD)
• Informed consent.

Exclusion criteria

• Severe depression.
• Bipolar disorder.
• Psychosis within the schizophrenic spectrum.
• Anorexia Nervosa.
• Substance abuse.
• Mental retardation.
• Dementia.
• Lack of informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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108 participants in 2 patient groups

Dialectical Behavior Therapy DBT

Active Comparator group

Description:

16 weeks DBT-treatment

Treatment:

Behavioral: DBT

CAMS

Active Comparator group

Description:

Collaborative Assessment and Management of Suicidality, CAMS-informed supportive psychotherapy

Treatment:

Behavioral: CAMS