Efficacy of Different Densities of Fractional Carbon Dioxide in Treatment of Post Burn Scars

Cairo University (CU)

Status: Completed

Conditions: Scar

Treatments: Device: Fractional Carbon Dioxide laser

Study type: Interventional

Funder types: Other

Identifiers

NCT03416660

cairou19

Details and patient eligibility

About

This study aims to compare effectiveness of different densities of carbon dioxide fractional laser in the treatment of postburn scar.

Full description

The study included 25 Egyptian patients with burn scars recruited from the Out Patient Clinic, Dermatology Department, Cairo University. Each has three post burn scars, assigned to monthly fractional Carbon dioxide laser sessions with a total of 3 sessions. parameters are :

Lesion A or part A parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 900µm spacing (7.4% density).

Lesion B or part B parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 600µm spacing (12.6% density).

Lesion C or part C parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 300 µm spacing (25.6% density).

3 mm punch biopsy is taken before and one month after last session for assessment of collagen via (Masson's trichrome strain). In addition clinical evaluation is done via Vancouver & Patient and Observer Scar Assessment Scale .

Enrollment: 25 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Burn scars of at least 1 year duration.

  • Patients with three separate lesions each of them about 2 to 5cm or patients with single lesion equal or more than 8 to 10cm.

Exclusion criteria

• • Pregnancy.

  • Lactation.
  • Oral retinoid drugs within the past 6 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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25 participants in 3 patient groups

Low density

Active Comparator group

Description:

Fractional carbon dioxide laser: Lesion A or part A parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 900µm spacing (7.4% density).

Treatment:

Device: Fractional Carbon Dioxide laser

Medium density

Active Comparator group

Description:

Fractional carbon dioxide laser : Lesion B or part B parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 600µm spacing (12.6% density).

Treatment:

Device: Fractional Carbon Dioxide laser

High density

Active Comparator group

Description:

Fractional carbon dioxide laser : Lesion C or part C parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 300 µm spacing (25.6% density).

Treatment:

Device: Fractional Carbon Dioxide laser