Efficacy of Different Medications as Adjuvants in Ultrasound-guided Supraclavicular Brachial Plexus Block in Forearm Surgeries

Al-Azhar University

Status: Active, not recruiting

Conditions: Upper Limb Surgery; Brachial Plexus Blockade

Treatments: Procedure: Group C (DM): Dexamethasone group; Procedure: Group B (MG): Magnesium group; Procedure: Group A (DT): Dexmedetomidine group

Study type: Interventional

Funder types: Other

Identifiers

NCT06949488

RHDIRB2018122002

Details and patient eligibility

About

This study is to evaluate whether addition of dexmedetomidine, dexamethasone and magnesium sulfate as adjuvants to bupivacaine in supraclavicular Brachial Plexus Blockade (BPB) for pain management assessed by VAS score.

Full description

This is a randomized controlled study involving 105 participants divided into three groups to assess the efficacy of adding dexmedetomidine, dexamethasone, and magnesium sulfate as adjuvants to bupivacaine in supraclavicular brachial plexus blockade during upper limb surgeries. The primary outcome is the postoperative Visual Analog Scale (VAS) score. The secondary outcomes are assessment of onset and duration of the block, patient satisfaction, and adverse effects.

Enrollment: 105 estimated patients

Sex: All

Ages: 21 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) status of I and II
• undergoing forearm surgeries

Exclusion criteria

• coagulopathies
• Local skin lesions
• Pregnancy
• Has a history of significant neurological, psychiatric, or neuromuscular disorders
• Patients refusing participation
• BMI > 40
• Patient with COPD. hypersensitivity or allergies to local anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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105 participants in 3 patient groups

Group A (DT): Dexmedetomidine group

Experimental group

Description:

A group of 35 participants will receive 18 ml of bupivacaine 0.5% plus dexmedetomidine 100 µg for the supraclavicular block.

Treatment:

Procedure: Group A (DT): Dexmedetomidine group

Group B (MG): Magnesium group

Experimental group

Description:

A group of 35 participants will receive 18 ml of bupivacaine 0.5% plus magnesium sulfate 150 mg in 2 ml of normal saline for the same block.

Treatment:

Procedure: Group B (MG): Magnesium group

Group C (DM): Dexamethasone group

Active Comparator group

Description:

A group of 35 participants will receive 18 ml of bupivacaine 0.5% plus dexamethasone 8 mg for the same block.

Treatment:

Procedure: Group C (DM): Dexamethasone group