Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty

Ankara Etlik City Hospital

Status: Completed

Conditions: Venous Insufficiency of Leg; Total Knee Arthroplasty

Treatments: Drug: Diosmin and Hesperidin Combination

Study type: Observational

Funder types: Other

Identifiers

NCT06753448

2024-1008

Details and patient eligibility

About

The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty. The main questions it aims to answer are:

Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery.

Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.

Enrollment: 190 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent unilateral primary total knee replacement surgery
• Patients who are functionally ASA 1, ASA 2 or ASA 3.

Exclusion criteria

• Patients >80 years or <18 years of age
• Patients with liver insufficiency
• Patients with allergy to diosmin or hesperidin
• Patients which are not capable to communicate

Trial design

190 participants in 2 patient groups

Study group

Description:

Participants will take diosmin and hesperidin combination in addition to standard therapy for 14 days after total knee replacement surgery.

Treatment:

Drug: Diosmin and Hesperidin Combination

Control group

Description:

Participants will only take standard therapy for 14 days after total knee replacement surgery.