Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM (DPMSM)

Los Angeles LGBT Center

Status

Completed

Conditions

Syphilis

Treatments

Behavioral: Incentive

Drug: Doxycycyline

Study type

Interventional

Funder types

Other

Identifiers

NCT02257658

PHS 398/2590

Details and patient eligibility

About

This pilot study will investigate the feasibility of conducting a large, randomized trial comparing a structural intervention to contingency management to reduce incident syphilis infections in an especially high risk group: HIV+ men who have sex with men (MSM) who have had syphilis twice or more since their HIV diagnosis. Subjects will be randomized to receive either QD doxycycline as syphilis prophylaxis or a financial incentive to remain STI free. The investigators will : 1) measure adherence to study visits in both arms; 2) measure adherence to the prophylaxis regimen; 3) measure any changes in risk behaviors among study participants and 4) to the extent possible in a small pilot study of short duration, compare effectiveness of doxycycline with that of a monetary incentive for remaining STI free.

Enrollment

30 patients

Sex

Male

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

HIV-infected MSM or transgender women who have sex with men
At least two documented and adequately treated episodes of syphilis since HIV diagnosis

Exclusion criteria

Had a known allergy or intolerance to doxycycline
Abused alcohol or other substances which in the opinion of the investigators would jeopardize adherence to study procedures