Efficacy of Epidural Analgesia in Lower Extremity Osteosarcoma

Istanbul University

Status: Unknown

Conditions: Osteosarcoma; Analgesia

Treatments: Procedure: Epidural Analgesia

Study type: Interventional

Funder types: Other

Identifiers

NCT04945512

2020/1831

Details and patient eligibility

About

In this study, the investigators aim to reduce complications in orthopedic malignancy surgeries and to increase the quality of life of patients who will be operated on.

Full description

In the preoperative period, the participants will be taken to the block room. The participants will be monitored, standard sedation will be applied.

Patients in the first group will be provided with preoperative and peroperative analgesia with an epidural catheter. The second group patient will be get no block. Afterwards, both groups will be operated under similar general anesthesia conditions. A patient-controlled analgesia device will be attached to each group of participants and their postoperative follow-up will be made.

Enrollment: 28 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• accepting the study protocol,
• age older than 18 years and younger than 80 years,
• undergoing lower extremity osteosarcoma surgery
• the American Society of Anesthesiologist (ASA) physical status of I-II-III

Exclusion criteria

• infection at the injection site
• coagulation disorder
• patients with central nervous system related disease
• septic patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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28 participants in 2 patient groups

Study group; Epidural catheter and PCA

Experimental group

Description:

Epidural catheter will be placed in the preoperative period. After induction, 10 ml of 0.25% bupivacaine will be administered through the epidural catheter and bupivacaine PCA will be started.

Treatment:

Procedure: Epidural Analgesia

Control group; No block, IC PCA

No Intervention group

Description:

Postoperative pain control will be achieved with intravenous morphine PCA.