Efficacy of Epidural Steroid for Controlling Pain After Primary TKA

Thammasat University

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: epidural triamsinolone; Drug: epidural lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02001259

orthoTU05

Details and patient eligibility

About

The purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after TKA

Full description

Epidural triamsinolone can reduce postoperative pain and longer duration of pain control after TKA

Enrollment: 108 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
• 50-85 years old
• ASA class 1-3

Exclusion criteria

• unable to perform epidural anaesthesia
• history of drug allergies: lidocaine, steroid
• renal impairment (CrCl <30 mL/min)
• liver impairment
• cognitive function disorders
• displacement of epidural catheter

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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108 participants in 2 patient groups

Epidural lidocaine

Active Comparator group

Description:

epidural lidocaine: 3 mL of 1% lidocaine with adrenaline and 3 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery

Treatment:

Drug: epidural lidocaine

epidural triamsinolone

Experimental group

Description:

epidural triamsinolone: 40 mg of triamsinolone (1 mL), 2.5 mL of 1% lidocaine with adrenaline and 2.5 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery

Treatment:

Drug: epidural triamsinolone