Efficacy of Er: YSGG Laser in Treatment of Peri-implantitis

Ain Shams University

Status: Completed

Conditions: Peri-Implantitis

Treatments: Device: Er: YSGG laser; Other: no therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05137821

FDASU-REC ID210314

Details and patient eligibility

About

This study will be carried out to evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology in the treatment of peri-implantitis as a primary objective.

To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives.

Full description

This study will be carried out to evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology in the treatment of peri-implantitis as a primary objective.

To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives.

The study was designed as an Ex Vivo study. Four periodontally and systemically healthy volunteers of both gender are included in this study for the formation of in vivo plaque biofilm. Each volunteer will wear a hard resin splint carrying six rough (machined implant; 3.3mm diameter, 8mm length) for 4 days to accumulate dental plaque naturally on the titanium surfaces of the implants.

Therefore, 24 implants will be assessed for Er: YSGG laser therapy in different bone defect simulators.

Enrollment: 3 patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sex: female or male.
• Age: 25 - 55 years.
• Medically controlled according to medical coding of review of systems (ROS)

Exclusion criteria

• Tobacco smoking for at least 6 months before the study enrollment

  • Participants with ill-fitting restorations in both upper first molars that affect the stability of the stent.
  • Participants not following oral hygiene instructions.
  • Participants on dental treatment during the study period.
  • Participants with a history of drug administration
  • Vulnerable group.
  • Participants with long-term mouthwash administration.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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3 participants in 2 patient groups

non tested comparative group

Experimental group

Description:

two sealed new implants as a control

Treatment:

Other: no therapy

Er: YSGG laser tested group

Experimental group

Description:

24 infected implants divided into four subgroups that will be decontaminated by Er: YSGG laser in various peri-implant defects

Treatment:

Device: Er: YSGG laser