Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial

The University of Texas System (UT)

Status: Completed

Conditions: Vasomotor Rhinitis

Treatments: Drug: esomeprazole; Drug: placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00745849

Efficacy Esomeprazole NAR

Details and patient eligibility

About

The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis

Enrollment: 43 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 18-80, symptoms of perennial rhinitis, negative epicutaneous skin testing to a panel of common aeroallergens, and ability to speak English

Exclusion criteria

• pregnancy or breast-feeding, evidence of positive skin tests to a common aeroallergen, treatment with a proton pump inhibitor within the month prior to enrollment, treatment with any other anti-reflux therapy within the last month on a daily basis or within the last two weeks on an as needed basis, and other gastrointestinal disorders leading to reflux symptoms

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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43 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

esomeprazole 40mg po bid

Treatment:

Drug: esomeprazole

2

Placebo Comparator group

Treatment:

Drug: placebo