Efficacy of Fish Oil Supplementation on Cognition in MCI Patients and the Influence of the APOE4 Allele

Wageningen University

Status

Completed

Conditions

Mild Cognitive Impairment

Treatments

Dietary Supplement: placebo, sunflower oil

Dietary Supplement: fish oil

Study type

Interventional

Funder types

Other

Identifiers

NCT00746005

2008/112

Details and patient eligibility

About

To study the short term effects of a pharmacological dose of fish oil on cognitive performance and on cerebral blood flow. Furthermore, we want to investigate whether carriers of the APOEε4 allele respond differently to fish oil treatment compared to non-carriers.

Enrollment

40 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Men and women
Diagnosed as having amnestic MCI: based on specific memory disturbances (cut-off of 1 sd, single or multiple domain amnestic MCI, according to Busse A et al37)
Presence of a principal caregiver willing to assist for a successful participation
Informed consent signed

Exclusion criteria

Current or recent (<4 weeks) use of fish oil supplements
Consumption of fish more than 2 times/week
Current use of dementia (Alzheimer) medication
Current use of acenocoumarol or other anti-thrombotic drugs (because of the high dose of fish oil)
Serious liver disease
Use of more than 4 glasses of alcohol per day
Unable to participate as judged by the responsible medical physician
Allergy to fish(oil)
Swallowing problems
Participation in another clinical trial less than 2 months before the start of the trial or at the same time