Efficacy of GONB in Patients of Migraine

Pain Medicine Department

Status and phase: Completed; Phase 4

Conditions: Chronic Migraine; Headache

Treatments: Drug: Greater Occipital Nerve Block with 0.9% saline; Drug: Greater Occipital Nerve Block with dexamethasone and lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT05679765

GONB for migraine

Details and patient eligibility

About

The study was carried to determine the analgesic efficacy of greater occipital nerve block in patients of migraine. It was a randomised controlled which took place from april 2022 - october 2022. Fifty patients suffering from migraine were included in the study. Patients in Group G were given greater occipital nerve block (GONB) with lignocaine and dexamethasone under ultrasound guidance while those in Group S were given saline 0.9% as placebo. Pain score using Numeric Rating Scale and number of headache days was assessed at four,eight and twelve weeks after the procedure as a primary outcome. Total headache days were recorded as a secondary outcome.

Enrollment: 50 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients between 18 to 60 years
• diagnosed case of migraine

Exclusion criteria

• Patients with known allergies to local anaesthetics
• pregnancy
• history of cranial or cervical surgery
• head injury
• headaches secondary to medication overuse
• patients with uncontrolled systemic disease like blood pressure, diabetes mellitus
• hypo or hyperthyroidism
• patient who had already received GONB or botulinum toxin type A therapy within last 6 months
• major psychiatric disorder
• history of chronic pain syndromes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

Group G

Experimental group

Description:

Greater occipital nerve block (GONB) under ultrasound guidance with lidocaine and dexamethasone on the side of headache

Treatment:

Drug: Greater Occipital Nerve Block with dexamethasone and lidocaine

Drug: Greater Occipital Nerve Block with 0.9% saline

Group S

Active Comparator group

Description:

Greater occipital nerve block (GONB) under ultrasound guidance on the side of headache with 0.9% Saline (Placebo)

Treatment:

Drug: Greater Occipital Nerve Block with dexamethasone and lidocaine

Drug: Greater Occipital Nerve Block with 0.9% saline