Efficacy of High-oleic Canola and Flaxseed Oils for Hypercholesterolemia and Cardiovascular Disease Risk Factors

University of Manitoba

Status and phase: Completed; Phase 2

Conditions: Cardiovascular Disease

Treatments: Dietary Supplement: High-Oleic Canola Oil; Dietary Supplement: High-Oleic Canola/Flaxseed Oil Blend; Dietary Supplement: Western Dietary Control

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00927199

B2007:071

Details and patient eligibility

About

The purpose of this study is to assess the efficacy of high-oleic canola oil and a high-oleic canola/flaxseed oil blend as compared to a typical Western diet on plasma lipids, fatty acid profiles, and risk factors associated with cardiovascular disease in hypercholesterolemic patients. Furthermore, the metabolism of dietary oleic acid and alpha-linolenic acid contained in high-oleic canola oil and flaxseed oil will be investigated.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fasting serum LDL-Cholesterol >3.0 mmol/L
• Body mass index (BMI) between 22-36 kg/m2

Exclusion criteria

• smoking
• use of lipid lowering therapy
• documented cardiovascular/atherosclerotic disease
• inflammatory disease
• diabetes
• uncontrolled hypertension
• kidney disease
• other systemic diseases
• cancer
• chronic alcohol consumption (> 2 servings/day)
• excessive exercise expenditure (> 4000 kcal/week)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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36 participants in 3 patient groups

High-Oleic Canola Oil

Experimental group

Treatment:

Dietary Supplement: High-Oleic Canola Oil

High-Oleic Canola/Flaxseed Oil Blend

Experimental group

Treatment:

Dietary Supplement: High-Oleic Canola/Flaxseed Oil Blend

Western Diet

Active Comparator group

Treatment:

Dietary Supplement: Western Dietary Control