Efficacy of Hyalase Hydro-dissection in Treatment of Carpal Tunnel: Randomized Double Blind Controlled Clinical Trial

Assiut University

Status: Completed

Conditions: Carpal Tunnel Syndrome

Treatments: Drug: Saline; Drug: Hyalase

Study type: Interventional

Funder types: Other

Identifiers

NCT03675295

IRB00009921

Details and patient eligibility

About

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve could offer symptoms and clinical improvement

Full description

Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities. Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. It occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.

Enrollment: 60 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• complaining of carpal tunnel syndrome of 3 month duration or more
• diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study

Exclusion criteria

• patient refusal
• infection at the site of intervention
• local anesthetic allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Comparator: Hyalase

Active Comparator group

Description:

injection of Hyalase + 10 cc saline injection nearby median nerve as hydro-dissection

Treatment:

Drug: Hyalase

Saline

Active Comparator group

Description:

Injection 10 cc saline injection as a median nerve hydro-dissection

Treatment:

Drug: Saline