Efficacy of Hyalase Hydro-dissection in Treatment of Carpal Tunnel: Randomized Double Blind Controlled Clinical Trial

A

Assiut University

Status

Completed

Conditions

Carpal Tunnel Syndrome

Treatments

Drug: Saline
Drug: Hyalase

Study type

Interventional

Funder types

Other

Identifiers

NCT03675295
IRB00009921

Details and patient eligibility

About

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve could offer symptoms and clinical improvement

Full description

Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities. Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. It occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.

Enrollment

60 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • adult patients
  • complaining of carpal tunnel syndrome of 3 month duration or more
  • diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study

Exclusion criteria

  • patient refusal
  • infection at the site of intervention
  • local anesthetic allergy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

Comparator: Hyalase
Active Comparator group
Description:
injection of Hyalase + 10 cc saline injection nearby median nerve as hydro-dissection
Treatment:
Drug: Hyalase
Saline
Active Comparator group
Description:
Injection 10 cc saline injection as a median nerve hydro-dissection
Treatment:
Drug: Saline

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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