Efficacy of Hydrocolloid Dressing vs. Topical Antibiotic on Wound Healing of Post-Punch Biopsy Wounds

University of Santo Tomas Hospital, Philippines

Status: Completed

Conditions: Biopsy Wound

Treatments: Drug: Mupirocin (drug); Drug: Hydrocolloid Dressing (DuoDERM CGF)

Study type: Interventional

Funder types: Other

Identifiers

NCT07064161

2023-06-047-TR-AP

Details and patient eligibility

About

The main objective of this study is to determine the efficacy of using hydrocolloid dressing on wound healing of post-punch biopsy wounds vs topical antibiotic. Specifically, it aims to measure the following parameters: the presence or absence of infection, the clinical estimate of reepithelialization, the clinical estimate of wound closure, scar formation, pigmentation of scar, and the cosmetic appearance of the wound.

The study is a double-blind randomized controlled trial which will be conducted at the Dermatology outpatient department and the private clinics of dermatology consultants of the University of Santo Tomas Hospital. Patients who will be included are those who are 18 to 64 years of age with clean cutaneous lesions. Excluded from this study are those who have infected wounds, those who have conditions with poor tendency to heal including diabetes mellitus, peripheral vascular disease, history of keloid formation, those currently receiving anticoagulation therapy or systemic corticosteroids, and those known to have hypersensitivity to topical antibiotics.

The primary outcome measure is the proportion of patients who achieved better overall healing when treated with hydrocolloid dressing.

Enrollment: 60 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients 18 to 64 years old with clean cutaneous lesions who underwent skin punch biopsy using 3-mm disposable biopsy puncher.

Exclusion criteria

• Patients with infected wounds.
• Patients with conditions with poor tendency to heal including diabetes mellitus, peripheral vascular disease, history of keloid formation, patients currently receiving anticoagulation therapy or systemic corticosteroids.
• Patients known to have hypersensitivity to topical antibiotics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Hydrocolloid Dressing

Experimental group

Description:

Skin punch biopsy wound treated with hydrocolloid dressing.

Treatment:

Drug: Hydrocolloid Dressing (DuoDERM CGF)

Topical Antibiotic

Experimental group

Description:

Skin punch biopsy wound treated with topical antibiotic.

Treatment:

Drug: Mupirocin (drug)