Efficacy of Inhalation of Essential Oil on the Reduction of Inhalants Craving

Chulalongkorn University

Status and phase: Completed; Phase 3

Conditions: Inhalants Craving

Treatments: Behavioral: Cue-induced inhalants craving; Combination Product: Perfume; Combination Product: Essential oil

Study type: Interventional

Funder types: Other

Identifiers

NCT03296943

Graduate School Grant 2553

Details and patient eligibility

About

Inhalants, which are neurotoxic central nervous system (CNS) suppressants, are frequently abused by young adults. Unlike other CNS depressants, including alcohol and opiates, no treatment is currently approved for inhalants dependence. In this report, a novel approach of substitution treatment for inhalants addiction was explored in a double-blinded, randomized, controlled crossover design to examine the effects of inhalation of essential oil (EO) and perfume (PF) on the reduction of cue-induced craving for inhalants in a cohort of thirty-four Thai males with inhalants dependence. The craving response was measured by the modified version of Penn Alcohol Craving Score for Inhalants (PACS-inhalants)

Enrollment: 34 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants with ability to smell if they could correctly identify 3 out of 5 odors, namely fish sauce, lemon, onion, basil, and jasmine.
• Individuals with inducible picture-cues inhalant craving based on a 50% increase in craving score from baseline.

Exclusion criteria

• Individuals with a history of major psychiatric disorders, including psychotic and mood disorders
• Individuals with illicit substance dependence other than inhalants
• Individuals with allergic reactions to essential oil or perfume.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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34 participants in 2 patient groups

Essential oil

Experimental group

Description:

Essential oil is prepared from the product of Thailada with manufacture standard ID 1087/2548 by Thailand Ministry of Industry. Essential oil is extracted by a cold compressed method from the lavandula angustifolia (lavender) grown in Australia.

Treatment:

Behavioral: Cue-induced inhalants craving

Combination Product: Essential oil

Perfume

Sham Comparator group

Description:

Perfume is the synthetic perfume of lavender flavor without essential oil.

Treatment:

Behavioral: Cue-induced inhalants craving

Combination Product: Perfume