ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

Assiut University

Status: Unknown

Conditions: Treatment Resistant Carpal Tunnel in RA Patients

Treatments: Other: saline; Drug: Insulin; Drug: Hylase

Study type: Interventional

Funder types: Other

Identifiers

NCT03394131

Hydrodissection of CT in RA

Details and patient eligibility

About

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection using insulin versus hyalase versus saline, ultrasounic guided as an effective treatment

Full description

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection of median nerve inside CT twice injections with interval 2 weeks using insulin and 10 cc saline versus hyalase and 10 cc saline versus 10 cc saline, ultrasounic guided as an effective treatment of CT

Enrollment: 90 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Rheumatoid arthritis in remission

Exclusion criteria

• active Rheumatoid arthritis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups, including a placebo group

Hyalase

Experimental group

Description:

injection and hydro-dissection of median nerve using hyaluronidase followed by 10 cc normal saline ultrasonic guided

Treatment:

Drug: Hylase

Placebo

Placebo Comparator group

Description:

injection and hydro-dissection of median nerve hydro-dissection using 10 cc saline injection ultrasonic guided

Treatment:

Other: saline

Insilin

Active Comparator group

Description:

injection and hydro-dissection of median nerve hydro-dissection using 10 IU insuline followed by 10 cc normal saline ultrasonic guided

Treatment:

Drug: Insulin