Efficacy of Intralesional Platelet Rich Plasma in Patients of De Quervain's Tenosynovitis

Muhammad Aamir Latif

Status: Completed

Conditions: De Quervain Tenosynovitis

Treatments: Other: Platelet Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT06651034

Mayo-2

Details and patient eligibility

About

De Quervain's tenosynovitis (DQT) was originally identified by Swiss surgeon Fritz de Quervain in 1895. It is a condition involving the entrapment of tendons within the first dorsal compartment of the wrist. In DQT, the sheaths surrounding the abductor pollicis longus (APL) and extensor pollicis brevis tendons thicken as they pass through a fibro-osseous tunnel near the radial styloid of the distal wrist. This thickening leads to pain, which worsens with thumb movements and radial or ulnar deviation of the wrist. Traditional treatment methods, such as corticosteroid injections and physical therapy, often provide only temporary relief and may not address the underlying inflammation effectively. Intralesional platelet rich plasma (PRP) therapy has emerged as a promising alternative, utilizing the patient's own growth factors and cytokines to promote healing and reduce inflammation. By investigating the efficacy of intralesional PRP in patients with DQT, this research aims to provide evidence for a minimally invasive treatment option that could enhance recovery times, reduce pain, and improve functional outcomes.

Enrollment: 67 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Either gender,
• Aged between 18 and 60 years
• Presenting with de quervain's tenosynovitis

Exclusion criteria

• Previous surgery or intervention forde quervain's tenosynovitis
• Local skin infection or osteomyelitis
• Pregnant or lactating mothers

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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67 participants in 1 patient group

PRP

Experimental group

Description:

Intralesional Platelet rich plasma

Treatment:

Other: Platelet Rich Plasma