Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section

Mahidol University

Status: Completed

Conditions: Morphine Adverse Reaction

Treatments: Drug: normal saline; Drug: naloxone

Study type: Interventional

Funder types: Other

Identifiers

NCT00890942

Si146/2009

Details and patient eligibility

About

The purpose of this study is to determine whether intramuscular naloxone 0.4mg. is effective in prophylaxis of intrathecal morphine induced pruritus after cesarean section.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient schedule for cesarean section ASA class 1

Exclusion criteria

• have contraindication for spinal block
• complicated pregnancy
• have history of drug abuse during pregnancy
• obesity BMI>35kg./m2

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

naloxone

Experimental group

Treatment:

Drug: naloxone

normal saline

Placebo Comparator group

Treatment:

Drug: normal saline