Efficacy of Jessener Solution Versus Intralesional Steroid in Treatment of Alopecia Areata (AA)

Al-Azhar University

Status and phase: Unknown; Early Phase 1

Conditions: Alopecia Areata

Treatments: Drug: Corticosteroids Acting Locally

Study type: Interventional

Funder types: Other

Identifiers

NCT04964349

Ahmed Kadah (Other Identifier)

Alazhar faculty of medicine

Eman Abd-ellatif (Other Identifier)

Details and patient eligibility

About

Alopecia areata is believed to be an autoimmune disease. Treatment primarily relies on intralesional and topical corticosteroids. This study was conducted to evaluate Jessener Solutionas a potential therapeutic modality of Alopecia Areataversusintralesional steroid as regards the efficacy, safety, tolerability, and patients' satisfaction.

Full description

Background Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss.Treatment primarily relies on intralesional and topical corticosteroids.Up till now, there is nouniversally proven therapy that induces and maintains remission of Alopecia Areata in all patients.

Aims The Aim of Study is to evaluate the efficacyof Jessener solution versus intralesional steroid in treatment of Alopecia Areata.

Patients and Methods The study will include 40 patients diagnosed clinically and dermoscopically as Alopecia Areata with more than two patches of alopecia areata were included. Two treatment modalities with intralesional corticosteroid and topical Jessener Solutionas were performed in two randomly selected patches. Three sessions were done, 3 weeks apart and were followed-up for three months. Evaluation was done using Mac Donald Hull and Norris grading system , Serial photographs and dermoscopic , trichoscopic examination every month will be done and patient will be score.

Enrollment: 40 estimated patients

Sex: All

Ages: 12 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1.Alopecia Areatamultilocuolaris.2.Age from18-50years old. 3.Wash out period is two months. 4.Ophiasis pattern alopecia areata.

Exclusion criteria

• Age less than 12 yearsand more than 40years old. 2.Patient under treatment.3.Patients having another dermatological condition affecting thescalpas eczema.4.Patients with psychiatric disorders.5.Pregnant and lactating females.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Intralesional cortisosteroid injection

Experimental group

Description:

Intralesional corticosteroid injection

Treatment:

Drug: Corticosteroids Acting Locally

jessener solution

Experimental group

Description:

topical jessener solution

Treatment:

Drug: Corticosteroids Acting Locally