Efficacy of JUC as Hand Rub Evaluated by Using European Standard 1500

The Hong Kong Polytechnic University

Status and phase: Completed; Phase 2

Conditions: Infectious Disease Transmission

Treatments: Drug: propan-2-ol; Drug: JUC solution

Study type: Interventional

Funder types: Other

Identifiers

NCT01824888

8-ZDA4 (Other Grant/Funding Number)

JUC-001-EN1500

Details and patient eligibility

About

JUC is a commercially available wound care spray. It is evaluated for the efficacy when using as a hygienic hand rub following the protocol described in the European standard EN 1500:1997 "Chemical disinfectants and antiseptics - Hygienic handrub - Test method and requirement (phase 2/step 2)". A crossover study to compare the JUC solution with 60% (v/v) propan-2-ol by using Escherichia coli K12 NCTC strain 10538 as test organism.

Full description

Before the intervention, the bactericidal activity of JUC was validated in accordance with the prEN 12054. A total of 15 volunteers were recruited, hands were washed immediately prior to the intervention. Then, both hands of each volunteer were immersed into a contamination fluid of E. coli. Then, hand rub was performed with JUC or alcohol. Culture samples were collected before and after the hand rub by rubbing the fingertips and thumb tips of each hand ont he base of a Petri dish containing appropriate medium. The culture inoculation, incubation, appropriate dilutions, and colony count were performed.

Enrollment: 15 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy and absence of significant illness

Exclusion criteria

• Visible wounds on hands

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Control

Active Comparator group

Description:

Following standard one-minute handwashing, both hands were immersed up to the mid-metacarpals for 5 seconds into a contamination fluid containing E. coli. Handrubs were performed by using 60% propan-2-ol into the cupped hands and rub vigorously for 30 seconds, the procedure was completed by a 5 seconds rinse of the fingers under running tap water and excess water was shaken off.

Treatment:

Drug: propan-2-ol

JUC solution

Experimental group

Description:

Following standard one-minute handwashing, both hands were immersed up to the mid-metacarpals for 5 seconds into a contamination fluid containing E. coli. Handrubs were performed by pouring 1.5 ml of JUC into the cupped hands and rub vigorously for 30 seconds, the procedure was completed by a 5 seconds rinse of the fingers under running tap water and excess water was shaken off.

Treatment:

Drug: JUC solution