Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl

Phramongkutklao College of Medicine and Hospital

Status and phase: Unknown; Phase 4

Conditions: Hypokalemia

Treatments: Other: KCl plus 0.45%NaCl; Other: KCl plus 0.9%NaCl

Study type: Interventional

Funder types: Other

Identifiers

NCT02721095

PMK1981

Details and patient eligibility

About

evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia

Full description

Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia.

Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.

Enrollment: 84 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Serum K+ 2.5-3.49 mmol/L
• No life threatening condition from hypokalemia

Exclusion criteria

• Pregnancy
• Volume overload, heart failure
• Hypotension
• Acute kidney injury
• Dysnatremia
• K+ shift
• Salt wasting nephropathy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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84 participants in 2 patient groups

0.9%NaCl

Experimental group

Description:

KCl plus 0.9%NaCl

Treatment:

Other: KCl plus 0.9%NaCl

0.45%NaCl

Active Comparator group

Description:

KCl plus 0.45%NaCl

Treatment:

Other: KCl plus 0.45%NaCl