Efficacy of Ketamine in Post Anesthesia Recovery Room

University of Alberta

Status: Completed

Conditions: Ketamine Adverse Reaction; Pain, Intractable; Pain, Acute; Pain, Postoperative; Pain, Refractory

Treatments: Drug: Ketamine

Study type: Observational

Funder types: Other

Identifiers

NCT04701008

Pro00102967

Details and patient eligibility

About

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Full description

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Enrollment: 143 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

• age ≥ 18
• significant pain despite narcotics used in post-anesthesia care unit
• ketamine ordered by attending anesthesiologist

Exclusion criteria

• Patient refusal to receive ketamine
• Patients undergoing cardiac surgery
• Patients who received no narcotics
• Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Trial design

143 participants in 1 patient group

Patients with significative post-operative pain despite

Description:

Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.

Treatment:

Drug: Ketamine