Efficacy of Laser Therapy for Periodontitis

University of Science and Technology, Yemen

Status: Not yet enrolling

Conditions: Periodontal Disease

Treatments: Procedure: Curettage (SRT) only; Procedure: Low diode diode laser + SRT; Procedure: High power diode laser + SRT

Study type: Interventional

Funder types: Other

Identifiers

NCT07013162

DLT-UST-YEMEN

Details and patient eligibility

About

The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after treatment, among some Yemeni individuals in Sana'a city.

Full description

This study aims to compare the clinical and immunological effects of traditional mechanical debridement alone versus combined treatment with diode laser (high and low power). The clinical parameters include Plaque Index (PI), Gingival Index (GI), Periodontal Pocket Depth (PPD), and Clinical Attachment Loss (CAL). Immunological parameters include IL-1β, IL-6, IL-8, and TNF-α levels in GCF. Participants will be selected from the Yemeni population residing in Sana'a City. The study will include a control group receiving conventional therapy and two test groups receiving diode laser therapy with high and low intensity settings, respectively. Measurements will be recorded at baseline (T0), one month after treatment (T1), and three months post-treatment (T2).

The goal is to determine whether adjunctive diode laser therapy provides additional clinical and immunological benefits compared to conventional treatment alone.

Enrollment: 21 estimated patients

Sex: All

Ages: 25 to 58 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Only patients meeting the following criteria will be enrolled into the study:

• Patient with generalized periodontitis (BOP and PPD ≥ 4 mm).
• Age group of 25-58 years old of periodontitis patients with at least 20 teeth present.

Exclusion criteria

• Smoker and qat chewer patients.
• Pregnant and lactating women.
• Patients take medications which might influence the periodontal tissue state.
• Patients having systemic health disorders which affect the periodontium by history.
• Patients who received periodontal treatment or antibiotic therapy 3 months before the study.

VI. Patient wearing intra-oral appliance or with dental prosthesis. :

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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21 participants in 3 patient groups

scaling and root planning (SRP)

Active Comparator group

Description:

Patients receive only subgingival curettage by curettes and ultrasonic scaler

Treatment:

Procedure: Curettage (SRT) only

High Diode Laser (H D Laser)

Experimental group

Description:

Patients recieved high power diode laser (2W) after curettage to pocket disinfection and tissue healing

Treatment:

Procedure: High power diode laser + SRT

Procedure: Curettage (SRT) only

Low Diode Laser (L D Laser)

Experimental group

Description:

Low power laser(0. 5W) is applicated to patient after curettage

Treatment:

Procedure: Low diode diode laser + SRT

Procedure: Curettage (SRT) only