Efficacy of Laser Versus Cryotherapy in the Treatment of Warts

The 306 Hospital of People's Liberation Army

Status

Completed

Conditions

Warts

Treatments

Other: Cryotherapy

Other: laser

Study type

Interventional

Funder types

Other

Identifiers

NCT01808443

306PLA-001

Details and patient eligibility

About

The purpose of this study is to test the efficacy of laser versus cryotherapy on the treatment of warts

Full description

Cutaneous warts were a common skin diseases caused by human papilloma virus (HPV) infection. Although warts may spontaneously resolve, many patients seek for treatment for various reasons. There are many kinds of treatments for cutaneous warts, including salicylic acid, cryotherapy, laser, etc. A recent high quality RCT confirmed that the cure rate of topical salicylic acid and frozen has no difference at six months, but the efficacy of laser versus cryotherapy on the treatment of warts remains unclear. Therefore, we designed a randomized controlled trial to test the efficacy of laser versus cryotherapy on the treatment of warts.

Enrollment

150 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients have cutaneous warts, including common warts(d≥1cm or n≥5 ), plantar warts, periungual warts, mosaic warts, which are suitable for cryotherapy and laser treatment .
patients aged eighting years and over, who have junior school degree or above

Exclusion criteria

Patients who have more than 20 warts
Patients who are currently participating in another trial for the treatment of their warts
Patients who took immunosuppressant drugs such as oral corticosteroids within the past three months.
Patients who are pregnant or ready for pregnancies or breast-feeding.
Patients who have impaired healing eg due to diabetes, vascular disease, vitamin A deficiency, hyperthyroidism and hypothyroidism.
Patients who have autoimmune diseases, eg SLE, dermatomyositis, scleroderma and other diseases .
Patients who have cold intolerance, eg cold urticaria, cryoglobulinaemia, cold agglutinin syndrome, Raynaud's syndrome.
Patients who have local injections intolerance.
Patients who have local hypoesthesia .
Patients who can not tolerate cryotherapy or laser treatment for their own reasons.