Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients

Cairo University (CU)

Status: Unknown

Conditions: Caries, Dental

Treatments: Other: chlorohexidine mouthwash; Other: licorice extract mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT03590977

CEBD-CU-2018-07-5

Details and patient eligibility

About

To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.

Full description

A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.

Enrollment: 52 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• over 18 years old
• co-operative patients
• not allergic to licorice
• not allergic to chlorohexidine

Exclusion criteria

• pregnancy
• allergic patients to licorice
• allergic patients to chlorohexidine
• lack of compliance
• evidence of parafunctional habits
• patients with periodontal disease
• xerostomia
• participants that receive any microbial agent two weeks prior to the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups, including a placebo group

licorice extract mouthwash

Experimental group

Description:

administration of a mouthwash containing licorice as a preventive measure to high caries risk patients (faculty of pharmacy, cairo university)

Treatment:

Other: licorice extract mouthwash

chlorohexidine mouthwash

Placebo Comparator group

Description:

administration of chlorohexidine 0.2% in 1:1 diluation mouthwash that is broad spectrum antimicrobial activity to high caries risk patients

Treatment:

Other: chlorohexidine mouthwash