Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers

Damascus Hospital

Status: Completed

Conditions: Peptic Ulcer Hemorrhage; Marginal Ulcer; Gastroduodenal Ulcer

Treatments: Drug: Omeprazole 40 MG

Study type: Observational

Funder types: Other

Identifiers

NCT03163680

G6-17

Details and patient eligibility

About

Determining the efficacy of low dose of PPI in management acute peptic ulcer bleeding

Full description

Determining the efficacy of low dose meaning 40 mg of omeprazole twice in management acute peptic ulcer bleeding

Enrollment: 295 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Criteria:

Inclusion Criteria:

High risk ulcers defined according to the Forrest classification With respect to high-risk stigmata, active bleeding was defined as a continuous blood spurting (Forrest IA) oozing (Forrest IB) from the ulcer base. A non-bleeding visible vessel at endoscopy was defined as a discrete protuberance at the ulcer base(Forrest IIA).

An adherent clot was one that was resistant to forceful irrigation or suction (Forrest IIB).

Exclusion Criteria:

ulcer was malignant non ulcerative bleeding such as angiodysplasia , a Mallory-Weiss tear

Trial design

295 participants in 1 patient group

Low Dose PPI

Description:

patients with upper upper gastrointestinal bleeding were treated in low dose of proton Bump inhibitor meaning 40 mg twice daily

Treatment:

Drug: Omeprazole 40 MG