Efficacy of Low Dose Propofol Given at the End of Sevoflurane Anesthesia for Prevention of Emergence Agitation in Pediatric Patient Undergoing MRI Scan

Khon Kaen University

Status: Not yet enrolling

Conditions: Emergence Agitation

Treatments: Drug: Normal saline; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT06218680

HE661348

Details and patient eligibility

About

The goal of this clinical trial is to compare Efficacy of low dose propofol(0.5 mg/kg) vs placebo given at the end of sevoflurane anesthesia for prevention of emergence agitation in pediatric patient undergoing MRI scan. The main question it aims to answer is "Can low dose propofol reduce the incidence of emergence agitation after general anesthesia?" Participants will be given propofol 0.5 mg/kg or saline according to the allocated group at the completion of MRI scan

Enrollment: 134 estimated patients

Sex: All

Ages: 1 to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 2-8 years
• ASA class I or II ,who schedule for MRI scan under sevoflurane anesthesia

Exclusion criteria

• Developmental delay
• Psychological and neurological disorders
• Abnormal airway
• Reactive airway disease
• Allergy to propofol, egg product
• Family history of malignant hyperthermia
• Need iv sedative medication before induction
• Obesity

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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134 participants in 2 patient groups, including a placebo group

group P

Experimental group

Description:

Receive 0.5 mg/kg of propofol intravenously at end of sevoflurane anesthesia

Treatment:

Drug: Propofol

group S

Placebo Comparator group

Description:

Receive saline intravenously at end of sevoflurane anesthesia

Treatment:

Drug: Normal saline