Efficacy of Mefenamic Acid and Hyoscine for Pain Relief During Saline Infusion Sonohysterography in Infertile Women

Mahidol University

Status: Unknown

Conditions: Infertility

Treatments: Drug: Mefenamic acid or Hyoscine or placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01060696

615/2551

Details and patient eligibility

About

The infertility patients who are performed saline infusion sonohysterography (SIS) for studying the pathology inside the uterine cavity has pain. From pilot study the pain score is 6.80. It will have more benefits if we can manage this procedure with less or no pain. Many studies have tried to decrease pain such as types of catheter, intrauterine lidocaine infusion. Some have real effects but no study with oral Mefenamic acid or Hyoscine before the procedure.The drugs are safe and easy to administration and chief.

Enrollment: 138 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• infertility female
• no history of HSG or Hysteroscopy

Exclusion criteria

• vaginal or pelvic infection
• abnormal Pap smear
• contraindications for Mefenamic acid including upper and lower GI ulcers, bleeding disorder, Asthma or allergies, renal disease, using Warfarin,Aspirin, Lithium, history of Mefenamic acid or Hyoscine allergies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

---

138 participants in 1 patient group

Hyoscine, Mefenamic acid, Placebo

Experimental group

Description:

Blind randomization to three groups. Mefenamic acid group Hyoscine group Placebo group

Treatment:

Drug: Mefenamic acid or Hyoscine or placebo