Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Mansoura University

Status and phase: Not yet enrolling; Phase 2; Phase 1

Conditions: Cancer

Treatments: Drug: Placebo; Drug: Memantine

Study type: Interventional

Funder types: Other

Identifiers

NCT05834231

2023

Details and patient eligibility

About

Memantine is a drug for the management of Alzheimer's Disease (AD) due to its promising neuroprotective properties. We hypothesize that Memantine possesses a beneficial role against chemotherapy-induced neuronal damages.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

histologically confirmed diagnosis of stage III colorectal cancer performance status < 2 according to Eastern Cooperative Oncology Group (ECOG) score adequate renal function (glomerular filtration rate ≥ 90)

Exclusion criteria

preexisting neuropathic or brain disorders, a previous use of chemotherapeutic agents including oxaliplatin use of drugs reported to have neuroprotective role

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Intervention

Active Comparator group

Treatment:

Drug: Memantine

Control

Placebo Comparator group

Treatment:

Drug: Placebo