Efficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring

Sohag University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Acne Scars; Acne Vulgaris

Treatments: Device: Dermaroller; Drug: Topical Vitamin C

Study type: Interventional

Funder types: Other

Identifiers

NCT03522922

MNC.001

Details and patient eligibility

About

This study aimed to evaluate the efficacy of dermaroller and topical vitamin C- either separate or combined- in treatment of post acne scars.

prospective randomized clinical trial that was The study was a randomized controlled trial, conducted in Sohag Dermatology outpatient clinic between June 2016 and of February 2018. 30 patients with acne scars were included.

All patients were informed about the entire procedure, medication, possible side effects and outcomes. A written informed consent was signed from each participant.

Full description

Study population:

Each study group included 10 patients. Detailed history and full clinical examination was conducted for each patient. Patients had 6 visits at one month interval to receive treatment and evaluated one month after the end of treatment visits.

The first group:

Patients received a series of six treatments by dermaroller at 4 weeks interval and no topical anti scar treatment in between sessions.

The second group:

Received a series of six treatments by dermaroller at 4 weeks interval with the same maneuver and instructions as first group and each session was followed by immediate application of topical vit.C serum plus once daily application in between sessions.

The third group:

received once daily topical vit.C serum capsule at night for six months. With monthly evaluation.

Assessment of patients during visits was as follow:

A) Clinical evaluation by B) Photographic documentation C) Patient satisfaction D) Safety assessment

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Facial acne scars

Exclusion criteria

• Active inflammatory acne.
• Active infection in the treatment area (e.g., herpes simplex and verrucae).
• Melanoma or lesions suspected of malignancy.
• Isotretinoin use in the past year.
• Dermatoses (e.g., eczema and psoriasis).
• Sunburn.
• Anticoagulant therapy.
• Systemic disease (diabetes, hypertension, collagen disease or bleeding tendency).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

30 participants in 3 patient groups

Dermaroller arm

Active Comparator group

Description:

Patients received a series of six treatments by dermaroller at 4 weeks interval and no topical anti scar treatment in between sessions.

Treatment:

Device: Dermaroller

Dermaroller + topical Vit. C arm

Active Comparator group

Description:

Patients received a series of six treatments by dermaroller at 4 weeks interval with the same maneuver and instructions as first group and each session was followed by immediate application of topical vitamin C serum plus once daily application in between sessions.

Treatment:

Drug: Topical Vitamin C

Device: Dermaroller

Topical Vit. C arm

Active Comparator group

Description:

Patients received once daily topical vitamin C serum capsule at night for six months. With monthly evaluation.

Treatment:

Drug: Topical Vitamin C