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Efficacy of Modified Ketogenic Diet (Atkins) in Management of Epilepsy

University Health Network, Toronto logo

University Health Network, Toronto

Status

Unknown

Conditions

Epilepsy

Treatments

Behavioral: ability to follow low carbohydrate diet
Behavioral: atkins diet

Study type

Interventional

Funder types

Other

Identifiers

NCT00188500
05-0027-AE

Details and patient eligibility

About

The purpose of this study is to determine whether patients with uncontrolled epilepsy can follow a low carbohydrate diet long-term and if so, how will that diet affect their seizures

Full description

In the management of drug-resistant epilepsy, many strategies have been examined. The Ketogenic Diet, high in fats and low in all other nutrients was observed to be of benefit. However, due to its complexedness and unpalatability, this diet is rarely used in the adult population. A recent small study showed seizure reduction with the Atkins Diet.

In this study, patients will be randomized into one of 2 groups- group 1 receiving limited dietary instruction for the Atkins Diet and group 2- receiving detailed dietary instruction. A seizure severity-matched control group will also take part. We will follow these patients over a period of 2 years looking at seizure frequency, weight, sustainability of the diet, effect on anti-epilepsy medication dosage, effect in cognition, quality of life and financial impact of the diet.

Patients will come to clinic to see the dietitian at specific intervals. cognitive testing will also be done at the beginning of the study and every 6 months thereafter. Patients will keep food charts, ketosis charts and seizure diaries.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:medically refractory partial epilepsy financial ability to pay for higher priced food

Exclusion Criteria:

  • Low BMI

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Central trial contact

Nina Politzer

Data sourced from clinicaltrials.gov

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