Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Asker & Baerum Hospital

Status and phase: Completed; Phase 4

Conditions: Osteoarthritis of the Knee

Treatments: Drug: fentanyl; Drug: ketorolac; Drug: bupivacaine; Drug: adrenaline; Drug: ropivacaine; Drug: morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT00562627

2007-003030-41

REK 1.2007.1603

EudraCT 2007-003030-41

Details and patient eligibility

About

Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge.

The aim of this study is to:

1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Full description

Total knee arthroplasty (TKA) is increasingly common in the treatment of knee osteoarthritis. TKA is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge.

Continuous epidural analgesia is often used for controlling pain after TKA. Recent studies describe a new method for pain control after total knee arthroplasty which consists of local infiltration with local anesthetics and adrenaline. This infiltrations can be combined with ketorolac and/or morphine. The aim of this study is to:

1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Enrollment: 102 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients at least 18 years of age
• scheduled for elective total knee arthroplasty
• ASA I-III
• signed written informed consent

Exclusion criteria

• age < 18
• ASA > III
• moderate or severe cardiac disease, bronchial asthma
• allergy against ropivacaine, ketorolac or morphine
• analgetic abuse
• pregnancy or nursing women
• severe psychiatric disease
• moderate to severe dementia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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102 participants in 3 patient groups

LIA IV

Experimental group

Description:

Local infiltration analgesia with ropivacaine and adrenaline and intravenous ketorolac and morphine

Treatment:

Drug: morphine

Drug: ropivacaine

Drug: adrenaline

Drug: ketorolac

LIA IA

Experimental group

Description:

Local infiltration analgesia with ropivacaine, adrenaline and ketorolac and morphine

Treatment:

Drug: morphine

Drug: ropivacaine

Drug: adrenaline

Drug: ketorolac

EDA

Active Comparator group

Description:

standard continuous epidural analgesia

Treatment:

Drug: fentanyl

Drug: adrenaline

Drug: bupivacaine