Efficacy of Mydriatic Drops in Premature Infants

Bulent Ecevit University

Status: Completed

Conditions: Retinopathy of Prematurity

Treatments: Drug: Drug used in the examination of premature infants.

Study type: Observational

Funder types: Other

Identifiers

NCT03448640

BulentEU

Details and patient eligibility

About

Because of the neonatologists reported that some infants had suffered from vomiting, bradycardia, hypotonia, and aspiration risk about 30-60 minutes after the fundus examination in the intensive care unit. The investigators observed the pupil dilation effects and side effects of tipple instillation of phenylephrine 2.5% plus tropicamide 0.5% ophthalmic drop combination which the investigators routinely used in ROP examination.

Full description

Purpose: To determine effect and vital change after topical application of phenylephrine 2.5% and tropicamide 0.5% three times for retinopathy of prematurity (ROP) examination in preterm infants.

Methods: Pupillary diameter, blood pressure, pulse rate, and oxygen saturation were monitored before, and after up to 24 hours 60 ROP screening examinations.

Enrollment: 60 patients

Sex: All

Ages: 32 to 34 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infants who were first ROP examinations
• infants born before 32 weeks.

Exclusion criteria

• Developmental ocular and/or systemic anomalies.
• Drug use that can affect vital values
• Unstable general condition
• Food intolerance
• Recurrent vomiting.